Publications
Improved Production of Novel Radioisotopes with Custom Energy Cyclone® KIUBE
The paper highlights the unique capabilities of the IBA Cyclone® KIUBE, particularly its variable energy feature. The application of this feature was demonstrated through hundreds of routine production runs of the 68Ga-liquid target with improved radionuclidic purity, longer shelf-life, and higher activity levels.
Al[18F]F-NOTA-Octreotide Is Comparable to [68Ga]Ga-DOTA-TATE for PET/CT Imaging of Neuroendocrine Tumours in the Latin-American Population
In the present work we investigated the clinical utility of Al[18F]F-NOTAOctreotide (Al[18F]F-OC) in comparison to [68Ga]Ga-DOTA-TATE in patients diagnosed with neuroendocrine tumours. Our aim was to verify the recently published, promising results for Al[18F]FNOTA-Octreotide in the Latin-American population. Al[18F]F-NOTA-Octreotide provided excellent image quality, detected NET lesions with high sensitivity and represents a highly promising, clinical alternative to [68Ga]Ga-DOTA-TATE.
A simplified protocol for the automated production of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ([18F] nifene) on an IBA Synthera® module
The α4β2 nicotinic acetylcholine receptor (nAChR) ligand 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ([18F]nifene) has been synthesized in 10% decay-corrected radiochemical yield using the IBA Synthera® platform (IBA Cyclotron Solutions, Louvain-la-Neuve, Belgium) with an integrated fluidic processor (IFP). Boc-nitronifene served as the precursor, and 20% trifluoroacetic acid (TFA) was used to deprotect the Boc-group after radiolabeling. By omitting the solvent extraction step after radiolabeling, the process was simplified to a single step with no manual intervention. [18F]Nifene was obtained in decay-corrected radiochemical yields of 10 ± 2% (n = 20) and radiochemical purity >99%. Typical specific radioactivities of 2700–4865 mCi/μmole (100–180 GBq/μmol) were measured at the end of synthesis; total synthesis times were about 1 h 40 min.
CRITICAL POINTS FOR IMPROVEMENT OF PERFORMANCE IN A SUMMARY OF MODULE SYNTHERA 18FDG.
R Catalan (1) G Quincoces (1) CHalezquer (1) M Ciordia (1) R Casanova (1) L Lopez-Sanchez (1) M Sanchez-Martinez (1) S Peña (1) J Richter (2) I Peñuelas (1) . Radiopharmaceutical Unit PET-GMP .Clínica Universidad Navarra.
Automated syntheses of N-SUCCINIMIDYL 4-[18F]Fluorobenzoate ([18F]SFB) AND N-[2-(4-18F-Fluorobenzamido) Ethyl]maleimide([18F]FBEM) using a customised IBA synthetiser
Shinn Dee Yeoh, Uwe Ackermann, Henri Tochon-Danguy, John Sachinidis, Rachel Mulligan and Stan Poniger
Development of a Radiosynthesizer Module Designed to Produce Florbetapir F 18 (18F-AV-45) for Clinical Trials
Leandro Silva, Pablo Pace, Carlos Hormigo, Patricia Zubata, Natalia Leonardi, Marcela Zubillaga, Jorge Nicolini, Ricardo Caro, Guillermo Casale, Nathaniel C. Lim, Tyler E. Benedum
Fully automated synthesis of apoptosis probe PET-18F-ML-10 with a multipurpose chemistry platform
Bernard Lambert, Jean-Jacques Cavelier, Guillaume Gauron, Christophe Sauvage, Cécile Kech, Timothy Neal, David Caron, Anat Shirvan, Ilan Ziv
Nucleophilic Labeling Reactions on Synthera: A Multipurpose Synthesis Platform
Alexander Schmitz & Richard Freifelder
Automated radiosynthesis of [18F]FAZA with Synthera radiochemistry box
A.G. Horti, M. Y. Kiselev, H.T. Ravert, R. L. Wahl, R.F. Dannals
Radiopharmacy Unit. Experience with the Synthera® chemistry module:
University Clinic of Navarra
Automated synthesis of [18F] fluoroacetate using a compact FDG synthesizer
Mori, Tetsuya, Arai, Ryo, Lambert, Bernard, Gameiro-Paris, Cristiana, Kosuga, Takeshi, Asai, Tatsuya, Fujibayashi, Yasuhisa, Okazawa, Hidehiko, Kiyono, Yasushi
Automated production of [18F] 2-fluoroethyl azide and a thymidine analogue using the Synthera module
Shinn Dee Yeoh, John I. Sachinidis, Henri Tochon-Danguy, Andrew M. Scott, Uwe Ackermann