Cu64Copper 64

Copper-64 is a radioisotope used in positron emission tomography (PET) and it has a half-life of 12,7h. It has been used for a long time in different applications (such as hypoxia imaging 64Cu-ATSM) and more recently as part of the theranostics pair with Copper 67 (for therapy).

To produce Copper 64,
we recommend this production route:

  • Recommended

    Cyclone:

    Cyclone® KIUBE

    Download the brochure

    For small 64Cu production, the most cost-effective solution is the irradiation of a liquid target at an energy around 14-16 MeV protons. Cyclone® KIUBE can have different fixed exit energy with its Custom Energy feature allowing the highest purity.

    Cyclone® KIUBE can also be equipped with a degrader foil on the liquid target

    More about Cyclone® KIUBE

    Target:

    Nirta® Liquid target

    The irradiation of enriched Ni via  64Ni(p,n)64Cu nuclear reaction, which is extensively prevalent and with almost no competitive copper radioisotopes involved in the process to deteriorate the purity.

    More about Nirta® liquid target

    Chemistry:

    Synthera® extension

    The technique is capable of delivering batches of  purified 64Cu ([64Cu]CuCl2); with only 30 min of post-process after End-Of-Beam (EOB), while avoiding the  technical difficulties arising from the use of conventional solid targets.

    More about Synthera® Extension

    Efficient for small productions

  • Recommended

    Cyclone:

    Cyclone® KIUBE

    Download the brochure

    For large scale production, 64Cu can be produced with the irradiation of a solid target at 12- 16 MeV. Cyclone® KIUBE can have different fixed exit energy with its Custom Energy feature allowing the highest purity.

    Cyclone® KIUBE can also be equipped with a degrador foil on the solid target.

    More about Cyclone® KIUBE

    Target:

    Nirta® solid target

    Nirta® Solid target can be used for irradiation of enriched 64Ni to produce 64Cu via 64Ni(p,n)64Cu nuclear reaction. The target is electroplated onto a silver backing with the Nirta® plating system. The target material is then  manually or automatically transferred to a hot cell.

    Since the enriched 64Ni is very expensive, recycling is recommended.

    More about Nirta® solid target

    Chemistry:

    Dissolution & Purification

    The irradiated target material is then dissolved and post-processed. Pinctada® platform is a complete industrial platform for the dissolution & separation for production of 64Cu.

    The purified radioisotope is obtained in the form of Copper-chloride and it can be used for further labelling manually or on Synthera®

    More about Pinctada® Metal

    Efficient for larger production

  • Recommended

    Cyclone:

    Cyclone® IKON

    Download the brochure

    64Cu can also be produced on the Cyclone® IKON using its variable energy and solid target.

    More about Cyclone® IKON

    Target:

    Nirta® solid target

    Nirta® Solid target can be used for irradiation of enriched 64Ni to produce 64Cu via 64Ni(p,n)64Cu nuclear reaction. The target is electroplated onto a silver backing with the Nirta® plating system. The target material is then  manually or automatically transferred to a hot cell.

    Since the enriched 64Ni is very expensive, recycling is recommended.

    More about Nirta® solid target

    Chemistry:

    Dissolution & Purification

    The irradiated target material is then dissolved and post-processed. Pinctada® platform is a complete industrial platform for the dissolution & separation for production of 64Cu-Chloride ([64Cu]CuCl2.).

    The purified radioisotope is obtained in the form of Copper-chloride and it can be used for further labelling manually or on Synthera®

    More about Pinctada® Metal

    Efficient for larger production

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